|Rozenwortel uit de Vanoise|
Adaptogens in Fatigue, Effect on Cognitive Functions
In total, more than 30 publications on the clinical efficacy of various R. rosea preparations can be found in the US National Library of Medicine’s PubMed database. The majority of these studies are of varying methodological rigor and concern cognitive functions and mental performance under fatigue.
The clinical trials using Schizandra chinensis (13 studies) and Eleutherococcus senticosus (11 studies) on mental performance in humans have been the subject of a recent review. A systematic review showed that adaptogens have a significant, beneficial, and specific effect on stress-induced symptoms under fatigue. It was observed thatR. rosea, in particular, significantly reduced symptoms of fatigue and improved attention after 4 weeks of repeated administration. Moreover, studies on healthy volunteers receiving single and repeated doses of the proprietary SHR-5® extract (R. rosea root; Swedish Herbal Institute; Gothenberg, Sweden) have demonstrated an anti-fatigue effect and improvement in cognitive functions during fatigue and in stressful conditions. Thus, one may conclude that repeated administration of R. rosea extract (SHR-5) exerts an anti-fatigue effect on healthy subjects and burnout patients expressing fatigue syndrome. This in turn increases the patient’s mental performance and ability to concentrate.
- Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Current Clin. Pharmacol. 2009;4(3):198-219.
- Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue – a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7:365-371
- Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-doseregimen.Phytomedicine. 2000;7:85-89.
- Olsson EMG, von Schéele B, Panossian AG. A randomized double-blind placebo controlled parallell group study of SHR-5 extract of Rhodiola rosea roots as treatment for patients with stress related fatigue.Planta medica. 2009;75:105-12.
Artikels over adaptogenen van Maurice Godefridi op infonu.nl