Topical administration of Rosmarinus officinalis leaf extract (RO-ext, 2 mg/day/mouse) improved hair regrowth in C57BL/6NCrSlc mice that experienced hair regrowth interruption induced by testosterone treatment. In addition, RO-ext promoted hair growth in C3H/He mice that had their dorsal areas shaved. To investigate the antiandrogenic activity mechanism of RO-ext, we focused on inhibition of testosterone 5α-reductase, which is well recognized as one of the most effective strategies for the treatment of androgenic alopecia. RO-ext showed inhibitory activity of 82.4% and 94.6% at 200 and 500 µg/mL, respectively. As an active constituent of 5α-reductase inhibition, 12-methoxycarnosic acid was identified with activity-guided fractionation. In addition, the extract of R. officinalis and 12-methoxycarnosic acid inhibited androgen-dependent proliferation of LNCaP cells as 64.5% and 66.7% at 5 µg/mL and 5 μM, respectively. These results suggest that they inhibit the binding of dihydrotestosterone to androgen receptors. Consequently, RO-ext is a promising crude drug for hair growth.
Promotion of Hair Growth by Rosmarinus officinalis Leaf Extract Kazuya Murata1, Kazuma Noguchi1, Masato Kondo2, Mariko Onishi2, Naoko Watanabe2, Katsumasa Okamura2, Hideaki Matsuda1,* Phytotherapy research
Andere kruiden voor de gezondheid van het haar zijn o.a. brandnetel en Oost-Indische kers. Lees meer op mijn website https://sites.google.com/site/kruidwis/fytotherapie/haargroei
Geen opmerkingen:
Een reactie posten